Calcitonin

Calcitonin, a thyroid hormone, increases bone density by increasing bone uptake of calcium and decreasing bone breakdown by osteoclasts.

 

 

Function

 

High blood levels of calcium increase calcitonin release, facilitating its uptake by bone.

Calcitonin is particularly important for the growth and development of children, and once adulthood hits, response to calcitonin decreases.

While calcitonin is not necessary for normal calcium homeostasis, it acts to decrease plasma calcium levels in two ways:

Calcitonin is being used as a treatment for osteoporosis, acting to reduce trabecular bone loss and risk of fracture.

 

Calcitonin can also be used for acute compression fractures for pain control.

 

Regulation of Expression

Calcitonin is produced by parafollicular (C) cells of the thyroid.

 

Consequences of Overexpression

 

 

Consequences of Underexpression

 

 

Signalling Pathways

 

 

Structure

Calcitonin is a 32 aa peptide