FSG has risen to include 25% of adult nephropathies. It is a clinical-pathological syndrome describing mulitple disease entities. Clinicially, there is proteinuria. Pathologically, focal segmental glomerular consolidation or scarring.
a simple case introducing clincial presentation and calling for a differential diagnosis to get students thinking.
There may also be an association with obesity.
Injury is caused by unknown entities in most cases, and inflammation ultimately leads to collagen scarring. Hyaline deposits can be seen in glomeruli.
Hypertension is a later presentation.
Proteinuria or nephrotic syndrome are frequent presenting conditions, with hematuria later developing.
Treatment can include corticosteroids, cyclophosphamide, and cyclosporin.
Dialysis and transplantation may also be needed.
Most people with FSGS develop chronic renal failure within 10 years.