Panic Disorder

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Introduction

Panic disorder is a discrete period of intense fear or discomfort that comes on unexpectedly and recurrently. Its peak onset is from 15-19 years, with a prevalence 3.5%.

 

 

 

The Case of...

a simple case introducing clincial presentation and calling for a differential diagnosis to get students thinking.

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Causes and Risk Factors

 

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Pathophysiology

 

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Signs and Symptoms

  • history
  • physical exam

History

  • tachycardia/palpitations
  • tembling/shaking
  • choking
  • nausea
  • sweating
  • shortness of breath/hyperventilation
  • chest pain/discomfort
  • dizzy
  • fear of losing control or going crazy
  • paresthesias
  • chills/hot flushes
  • there is persistent worry that things could happen again
  • recurrent unexpected panic attacks, including at least four of the above symptoms, which develop abruptly and peak within 10 minutes
  • there needs to be changes in behaviour or persistent fear of future attacks or health implications

can be with or without agoraphobia

 

Physical Exam

 

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Investigations

  • lab investigations
  • diagnostic imaging

Lab Investigations

Diagnostic Imaging

 

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Differential Diagnosis

 

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Treatments

mild PD can be treated with behavioural therapy

moderate PD can benefit from antidepressants (except bupriopion)

severe PD indicates additions of benzodiazepines (clonazepam, lorazepam)

 

combination therapy alone may actually worsen long-term outcomes, compared with CBT (Foa et al, 2002)

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Consequences and Course

 

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Resources and References

Foa EB, Franklin ME, Moser J. (2002). Context in the clinic: how well do cognitive-behavioral therapies and medications work in combination? Biol Psychiatry. 52(10):987-97.

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Topic Development

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