Sjogren's syndrome

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Introduction

Sjogren's syndrome is a chronic inflammatory disorder characterized by decreased lacrimal and salivary gland function.

a simple case introducing clincial presentation and calling for a differential diagnosis to get students thinking.

It can occur in a primary form or secondary to other rheumatic conditions.

Sjogren's syndrome is charactierized by lymphocytic infiltration into tissues or organs.

B cell expansion

Sicca symptoms describe xeropthalmia (dry eyes) and xerostomia (dry mouth).

Can have extra-glandular involvement: skin, joints, muscles, thyroid gland, lungs, heart, GI tract, liver, kidneys, pancreas, CNS, PNS

associated increased risk of lymphoma - 16-44%

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