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Ceftriaxone
3rd generation cephalosporin
- uses
- mechanism
- dose and half-life
- adverse drug reactions
- counter-indications and drug interactions
- metabolism and excretion
- dependency
Uses
- very good for gram positive bacteria; used as emperic therapy for pneumonia
- crosses membranes so can be used in meningitis
- reduced coverage for gram negative bacteria
Mechanism
- inhibits PBPs, preventing cell wall synthesis
- more resistant to beta-lactamase than penicillins
Dose and Half Life
- iv
- IM
Adverse Drug Reactions
short term
Once daily dosing can cause biliary sludging.
long term
Counter-Indications and Drug Interactions
- do not use in jaundiced baby
Metabolism and Excretion
- half excreted in liver, half in kidney