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Clindamycin
lincosamide antibiotic
- uses
- mechanism
- dose and half-life
- adverse drug reactions
- counter-indications and drug interactions
- metabolism and excretion
- dependency
Uses
- anaerobic infections
- aerobic gram positive bacteria
- bacteroides (gram negative intestinal)
Mechanism
- inhibits protein initiation
- penetrates most tissues, but not CSF
Dose and Half Life
- 2.5 hours
Adverse Drug Reactions
- GI toxicity
- pseudomembranous colitis
- shouldn't be used during pregnancy for reasons that are not clear
Counter-Indications and Drug Interactions
Metabolism and Excretion
- metabolized in liver
- excreted in both urine and stool