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Dopamine

important neurotransmitter that acts on the CNS and peripherally through the symapthetic nervous system.

Uses

low dose DA used in congestive heart failure
precursor levodopa used to treat Parkinson's disease

Mechanism

Agonists

bromocriptine - used as well; fails after 5-7 on average

Antagonists

phenothiazines

Dose and Half Life

Given parenterally in 40, 80, 160 mg/ml for injection, and 80, 160, 320 mg/ 100 ml in 5% D/W for infusion

low dose: D1 receptors: dilates renal arteries, increasing GFR
medium dose: β1 agonist
high dose: α1 agonist: vasoconstriction (bad)

Side Effects

short term

long term

Counter-Indications

Metabolism and Excretion

Dependency