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Drug-drug interactions
Drug-drug interactions increase quickly with the number of drugs given, up to 100% for 8 drugs
Mechanisms can occur in various ways
- Absorption can be impaired (ie calcium and bisphosphonates)
- Cytochrome P450 activity can be affected, ie sertraline and phenyltoin
- Drugs can have the same effect, ie ACE and K
- Drugs can have the opposite effect, ie AChE inhibitor and anticholinergic drugs
- impaired excretion, ie thiazide and lithium
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