- medications
- pharmacokinetics
- dosage calculations
- routes of administration
- e-CPS
- Dal Pharm Drug Info
- RxFiles
Section Links
Valacyclovir
antiviral; metabolized to acylovir
- uses
- mechanism
- dose and half-life
- adverse drug reactions
- counter-indications and drug interactions
- metabolism and excretion
- dependency
Uses
- HSV and VSV
- 2
Mechanism
- activated (only) by viral thymidine kinase
- accumulates in infected host cells
- inhibits viral DNA synthesis by competitive inhibition and chain termination
Dose and Half Life
- better bioavailability than acyclovir
Adverse Drug Reactions
short term
- if urine is too concentrated, excreted acyclovir crystalizes, necessitating
long term
Counter-Indications and Drug Interactions
- excreted in urine
Metabolism and Excretion