Esophageal fibrosis can lead to dysphagia.
Can begin in hands, face, or mouth
most commonly affected systems
skin - scleroderma, calcinosis, telangiectasia, Raynaud's disease.
lungs - interstitial lung disease, pulmonary hypertension, pleural effusions
kidneys - scleroderma renal crisis
heart - arrhythmias, pericarditis, myocardial fibrosis
autoantibodies include ANA, anti-centromere, anti-Scl-70, and anti-RNP
Urinalysis
micro
limited cutaneous scleroderma
vascular phenomenon tend to be grouped together: Raynaud's, telangiectasia, pulmonary hypertension
CREST syndrome
diffuse cutaneous scleroderma
often centromere antibody
Renal crisis
can lead to microangiopathic hemolytic anemia: