- medications
- pharmacokinetics
- dosage calculations
- routes of administration
- e-CPS
- Dal Pharm Drug Info
- RxFiles
Section Links
Bupropion (Wellbutrin, Zyban)
antidepressant, antismoking drug
- uses
- mechanism
- dose and half-life
- adverse drug reactions
- counter-indications and drug interactions
- metabolism and excretion
- dependency
Uses
- depression
- quitting smoking
- improves sexual function
Mechanism
- norepinephrine-dopamine reuptake inhibitor
Dose and Half Life
Higher doses appear more effective
For quitting smoking
Continue smoking for first 1-2 weeks, then stop completely
- 150 mg qAM x 3 days
- 150 mg BID x 7-12 weeks
- consider maintenance up to 6 months
Adverse Drug Reactions
- insomnia
- dry mouth
Counter-Indications and Drug Interactions
- seizure disorder
- eating disorder
- MAOI use in past 14 days
Metabolism and Excretion