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Trimethoprim-sulfamethoxazole (TMP/SMX)
TMP/SMX (Septra, Biaxin) is combination of two antibacterial drugs that both inhibit folate synthesis.
- uses
- mechanism
- dose and half-life
- adverse drug reactions
- counter-indications and drug interactions
- metabolism and excretion
- dependency
Uses
- Pneumocystis jiroveci-induced pneumonia
- toxoplasmosis
Mechanism
- cells
- proteins
Dose and Half Life
Adverse Drug Reactions
common
- frequent mild allergic reactions
uncommon
- can cause acute interstitial nephritis, tubular crystalization, snf decreased tubular secretion of Cr and K+
Counter-Indications and Drug Interactions
Metabolism and Excretion