Follicular Stimulating Hormone

 

Follicular Stimulating Hormone (FSH) is a key reproductive hormone. It acts on primary follicles by binding to granulosa cells and acting to increase fluid secretion into the follicular cavities. This causes them to grow rapidly. Granulosa cells also respond by secreting increasing levels of estradiol into the circulation.

 

Function

 

FSH, together with LH, prmotes estrogen production by the ovary. It also induces egg development.

In males, FSH induces sperm development.

 

Regulation of Expression

FSH is essentially absent until puberty. It is regulated by GnRH release from the hypothalamus.

 

Consequences of Overexpression

 

 

Consequences of Underexpression

 

 

Signalling Pathways

 

 

Structure