Lutenizing Hormone
Lutenizing Hormone (LH) is an important reproductinve hormone.
- functions
- regulation of expression
- consequences of overexpression
- consequences of underexpression
- signalling pathways
- structure
Function
LH promotes ovulation and stimulates progesterone following egg release. Together with FSH, it stimulates secretion of estrogen from the ovary.
In males, LH stimulates production of testosterone in the testes.
Regulation of Expression
LH is essentially absent until puberty. It is regulated by GnRH release from the hypothalamus.
Consequences of Overexpression
Overexpression of PRL (hyperprolactinemia) can lead to galactorrhea
Consequences of Underexpression
Signalling Pathways
Both PRL and GH have similiar affinities for the PRL receptor.
Structure
Prolactin is a 199 amino acid hormone with 16% homology to growth hormone.