Prolactin
Norepinephrine (NE)
- functions
- regulation of expression
- consequences of overexpression
- consequences of underexpression
- signalling pathways
- structure
Function
TSH induces thyroxine and T3 release from the thyroid gland. T3 and T4 provide negative feedback to the hypothalamus and pituitary.
Regulation of Expression
Tonic release of TRH induces TSH.
Consequences of Overexpression
Overexpression of PRL (hyperprolactinemia) can lead to galactorrhea
Consequences of Underexpression
Signalling Pathways
Both PRL and GH have similiar affinities for the PRL receptor.
Structure
Prolactin is a 199 amino acid hormone with 16% homology to growth hormone.