Paget's Disease
- causes and risk factors
- signs, symptoms and diagnosis
- pathophysiology
- treatments
- consequences and course
- the patient
- health care team
- community involvement
- resources and references
Causes and Risk Factors
Tends to begin in people over age 40, mainly in Caucasians.
Purposeless hyperturnover occurring in part of the bone. No one knows why this occurs.
There may be some connection with paramyxovirus.
Signs, Symptoms, and Diagnosis
About 70% of people have mild or asymptomatic.
Can result in changing bone shape or size, bome pain, pathologic fractures, kidney stones due to increased serum calcium, high output cardiac failure (dunno why), and neurologic syndromes.
Bone alkaline phosphatase can increase, as can serum calcium.
The majority of cases are picked up throught imaging as asymptomatic disease.
Pathophysiology
A mosaic pattern occurs as the bone becomes structurally abnormal, with bits of hardened bone
Treatments
blocking osteoclasts using bisphosphonates or
Consequences and Course
sarcoma is a rare but almost always fatal result of Paget's disease.
The Patient
Health Care Team
Community Involvement
References