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Contrast Nephrotoxicity
Usually occurs within the first 48 hours after dye administration.
Risk depends on previous kidney function, volume status, other potentially nephrotoxic medications, and other comorbidities.
Vasoconstriction follows adenosine activity.
Release of ROS.
Preventing Nephrotoxicity
Hydration is the most important prophylaxis. Give 75 cc/hr pre- and post-dye.
Mucomyst can also be helpful, along with 1200 BID bicarbonate.
Stop ACE/ARB/diuretics/NSAIDs prior to dye.
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