Acidosis

Acid-base homeostasis is very important for metabolic functioning, especially affecting cardiovascular, respiratory, and neurological tissues. Protein conformation and activity is profoundly influenced by pH, which is accordingly tightly regulated.

Normal bicarbonate (HCO3) serum concentration is 24 mEq/L, while the normal pCO2 is 40 mHg.

 

 

Types of Acidosis

 

Acidosis can be metabolic or respiratory. Each disorder has an approprate compensation. Inadequate compensation or ove

  • metabolic
  • respiratory

Metabolic Acidosis

Metabolic acidosis occurs when metabolic or dietary acid production exceeds acid secretion, and is characterized by a decrease in serum bicarbonate concentration.

 

Non-anion gap acidosis results from HCl gain (intake), HCO3 loss (renal tubule acidosis, acetazolamide, diarrhea, ostomy loss), or decreased HCO3 production (distal renal tubular acidosis, aldosterone deficiency/resistance) or:

  • Hyperalimentation
  • Aldosterone deficiency or insensitivity
  • Renal tubular acidosis (diagnose with urine anion gap, as described below)
  • Diarrhea (HCO3 loss)
  • Ureteric diversion
  • Pancreatoduodenal fistula

 

Important causes of wide anion gap acidosis include:

  • Methanol (formate metabolite)
  • Uremia
  • Diabetic ketoacidosis, also starvation
  • Paraldehyde
  • Isozaizid/Isopropanol/Iron
  • Lactic acidosis
    • increased anaerobic metabolism: ischemia, shock, septicemia, profound hypoxemia
    • decreased lactate metabolism in liver: alcohol, thiamine deficiency, metformin accumulation
  • Ethylene glycol (oxalate metabolite)

Respiratory Acidosis

Respiratory acidosis occurs due to alveolar hypoventilation. This can occur in respiratory depression due to drugs, alcohol, increased airway resistance due to asthma, impaired gas exchange in fibrosis or pneumonia, or, most commonly, with COPD.

The kidney excretes increased H+ and reabsorbs increased bicarbonate in attempts to compensate.

 

 

 

 

Signs, Symptoms, and Diagnosis

 

  • history
  • physical exam
  • lab investigations
  • approach to blood gases

History

Physical Exam

 

Respiratory compensation of metabolic acidosis can lead to hyperventilation.

 

Acidosis can lead to somnolence, confusion, and carbon dioxide narcosis. Asterixis may be present.

Lab Investigations

 

blood

  • CBCD
  • chloride: normal in anion gap metabolic acidosis
  • BUN and creatinine
  • glucose
  • lactate
  • ketones
  • serum alcohol/methanol
  • serum osmolality; can indicate ingestion of methanol, ethylene glycol, ethanol?

urine

  • urinalysis
  • electrolytes
  • oxalate crystals (ethylene glycol)
  • urine anion gap (Na+ + K+- Cl-) : positive charge suggests lack of NH4+, seen in type I renal tubular acidosis

arterial blood gases

  • as described in next section

Approach to Blood Gases

 

Acidemia requires arterial blood gases for diagnosis.

A low HCO3 suggests metabolic acidosis, while a high pCO2 points toward respiratory acidosis.

 

Compensation

In metabolic acidosis, each drop in HCO3 should equal drop in pCO2.

In respiratory acidosis, each increase of 10 pCO2 should equal an increase in HCO3

 

Anion Gap

The anion gap equals Na - (HCO3 + Cl). It is normally 10-14 and represents proteins, ammonium, and other anions.

Part of the AG is mediated by albumin. For each drop in serum albumin of 10g/L, lower the baseline AG by 3.

 

If the AG is elevated, compare with the decrease of HCO3.

  • If the increase in AG < decrease in HCO3, there is a co-existing non-AG metabolic acidosis
  • If the increase in AG > decrease in HCO3, there is a co-existing metabolic alkalosis

 

Osmolar gap

The osmolar gap is measured - calculated osmolality, and is calculated as 2Na + BUN + glucose (all units in mmol/L).

A normal gap is <10. If not consider causes of additional osmoles, such as

  • methanol
  • ethylene glycol
  • ESRD
  • alcoholic ketoacidosis
  • formaldehyde

 

 

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Treatments

 

ABCs

oxygen, IV, intubation

NaHCO3 1-2 amp bolus

Monitor and treat hyperkalemia

consider NaHCO3 if:

be cautious of causing hypokalemia, of volume overload, or of overshoot alkalosis.

 

Treat underlying cause.

 

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Consequences and Course

 

 

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Resources and References